Idebenone is used to treat Leber's Hereditary Optic Neuropathy (LHON) by improving or stabilizing visual acuity. It acts as an electron carrier in mitochondria to improve cellular energy and reduce oxidative stress.
Idebenone is a synthetic short-chain benzoquinone and a structural analog of coenzyme Q10. It acts as an electron carrier in the mitochondrial electron transport chain, potentially bypassing complex I defects often associated with Leber's Hereditary Optic Neuropathy (LHON). This can help to restore cellular energy production and reduce oxidative stress in retinal ganglion cells, thereby improving or stabilizing visual acuity in some patients with LHON.
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