5-HTP

5-HTP supports mood and sleep by boosting serotonin, but may cause nausea or serotonin syndrome with other serotonergics.

About 5-HTP

5-HTP (5-Hydroxytryptophan) is a naturally occurring amino acid derived from Griffonia simplicifolia seeds. It serves as a direct precursor to serotonin, a neurotransmitter involved in mood regulation, sleep, appetite, and pain perception. Supplementation with 5-HTP is often used to support mood, improve sleep quality, potentially aid in appetite control, and reduce migraine frequency. Typical dosages range from 50-300mg daily. While generally safe, common side effects include gastrointestinal discomfort such as nausea, diarrhea, and stomach cramps. A rare but serious risk is serotonin syndrome, particularly when 5-HTP is combined with other serotonergic medications. It is crucial to consult with a healthcare professional before taking 5-HTP, especially for individuals taking other medications or with pre-existing medical conditions to mitigate potential risks and ensure safe usage.

Key Information

Category
Amino Acids
Use Type
Inside Body

Compare All Forms

Compare different forms of 5-HTP by bioavailability, conversion rates, and active ingredient content:

Form Tier Steps 5-HTP
(mg) 		Bioavailability Action
5-HTP (5-Hydroxytryptophan)

5-HTP supports mood and sleep by boosting serotonin, but may...

 Tier 2 1 — Moderate bioavailability form. Reliable form that works well but requires 1-2 step conversions by the body. Good balance of cost and effectiveness. View →

Scientific Evidence

Shaw, K., Turner, J., Del Mar, C. (2002). Tryptophan and 5-hydroxytryptophan for depression. Cochrane Database of Systematic Reviews, (1).
Birdsall, T. C. (1998). 5-Hydroxytryptophan: a clinically-effective serotonin precursor. Alternative Medicine Review, 3(4), 271-280.
Ribeiro, C. A. (2000). L-5-Hydroxytryptophan in the prophylaxis of children with recurrent migraine. Pediatric Neurology, 22(1), 68-73.