About Alpha-Lipoic Acid
Alpha-lipoic acid (ALA) is a naturally occurring and synthetically produced antioxidant compound crucial for energy production within cells. It acts as a potent antioxidant, regenerating other antioxidants and protecting against oxidative stress. ALA is commonly supplemented for its potential benefits in managing diabetes, alleviating neuropathic pain, and supporting cognitive function. While generally safe, ALA can cause gastrointestinal side effects and may interact with medications that affect blood sugar levels. Individuals should consult with a healthcare professional before taking ALA supplements, especially those with pre-existing medical conditions or those taking medications.
Key Information
Compare All Forms
Compare different forms of Alpha-Lipoic Acid by bioavailability, conversion rates, and active ingredient content:
| Form | Tier | Steps |
Alpha-Lipoic Acid (mg) |
Bioavailability | Action |
|---|---|---|---|---|---|
| Alpha-Lipoic Acid (ALA) | Tier 3 | 3 | — | Basic/low bioavailability form. Cheap raw material with poor absorption or high GI distress. Often poorly utilized by the body, requires 3+ conversion steps. | View → |
Scientific Evidence
Numerous studies published in journals such as Diabetes Care, Archives of Biochemistry and Biophysics, and the Journal of Alzheimer's Disease support the use of ALA for its antioxidant, anti-diabetic, and neuroprotective effects. Meta-analyses and systematic reviews provide comprehensive evaluations of the available evidence. Trials investigating the efficacy and safety of ALA in diabetic neuropathy are particularly well-documented.