Creatine Ester

Inside Body
Inside: Harmless

Creatine ester is a form of creatine, often touted for potentially better absorption and bioavailability compared to creatine monohydrate. It is formed by esterifying creatine, theoretically improving...

Creatine ester is a form of creatine, often touted for potentially better absorption and bioavailability compared to creatine monohydrate. It is formed by esterifying creatine, theoretically improving its lipophilicity and thus membrane permeability. However, research comparing its efficacy to creatine monohydrate has shown conflicting results, with some studies suggesting it is less effective.

Key Information

Inside Body Harmful Score

Harmless

Common Dosage

2-5g daily

Source Type

synthetic

Production Process

Creatine is esterified with ethanol to form creatine ethyl ester.

Use Type

Inside Body

Potential Benefits

Esterification of creatine aimed to enhance absorption and muscle creatine storage, but studies haven't shown superiority over creatine monohydrate. Creatine esters do not appear to improve muscle uptake or performance beyond what is achievable with creatine monohydrate.

2/5

Possible Side Effects

Gastrointestinal Distress

Stomach upset, diarrhea, or cramping may occur in some individuals.

low
Muscle Cramps

Creatine supplementation is sometimes associated with muscle cramps, likely due to electrolyte imbalance, dehydration, or increased exercise intensity. The link is not definitively proven, and individual susceptibility varies.

low

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