D-Aspartic acid (DAA) is a naturally occurring amino acid isomer involved in hormone regulation and neurotransmitter function. Supplementation is primarily investigated for its potential to boost test...
D-Aspartic acid (DAA) is a naturally occurring amino acid isomer involved in hormone regulation and neurotransmitter function. Supplementation is primarily investigated for its potential to boost testosterone levels and improve sperm quality, although results are inconsistent and may depend on individual factors. While generally safe, some users may experience mild side effects such as stomach discomfort or headaches. Further research is needed to fully understand its long-term effects, optimal dosage, and efficacy across diverse populations and baseline hormone levels. DAA's role in neurotransmitter systems also warrants further investigation to fully elucidate its effects on brain function.
Key Information
Inside Body Harmful Score
Common Dosage
2000-3000mg daily
Source Type
natural
Production Process
D-Aspartic acid is produced through chemical synthesis by converting L-aspartic acid, its enantiomer, into its D form. This involves various chemical reactions to invert the stereochemistry at the chiral center.
Use Type
Inside BodyPotential Benefits
Enhances mental processes involved in thinking, learning, and remembering, including memory, attention, focus, and processing speed. Benefits range from improved mental clarity to significant enhancements in cognitive abilities, especially in those with cognitive decline.
Glycine functions as an inhibitory neurotransmitter, primarily in the spinal cord and brainstem, reducing neuronal excitability and potentially providing calming and anti-anxiety effects. It helps regulate neuronal firing and excitability within the central nervous system.
D-Aspartic acid may increase testosterone production by stimulating the release of LH and FSH, which signal the testes to produce testosterone. This effect is potentially more significant in individuals with lower baseline testosterone levels.
D-Aspartic acid may enhance male fertility by boosting testosterone and LH production, leading to improved sperm quality and motility. This improvement is attributed to DAA's role in hormonal regulation and sperm production.
Possible Side Effects
Headaches are a common side effect characterized by pain in the head, ranging from mild to severe, potentially accompanied by nausea and sensitivity to light/sound. They can be triggered by various factors, including dehydration, stress, or medication.
Mood changes involve fluctuations in emotional state, ranging from irritability to euphoria, impacting daily life and well-being. These changes may be caused by physiological or psychological factors, necessitating careful evaluation.
Irritability is an increased feeling of frustration and annoyance, leading to heightened reactivity to stimuli. It can manifest as restlessness and difficulty concentrating.
Stomach discomfort can manifest as mild upset, nausea, or diarrhea. Symptoms are typically mild and resolve on their own, but persistent or severe cases should be medically evaluated.
Scientific Evidence
Roshanzamir, F., & Safavi, S. M. (2017). The effect of D-aspartic acid on seminal parameters in infertile men: a systematic review and meta-analysis. International Journal of Reproductive Biomedicine, 15(1), 1–8. Topo, E., et al. (2009). The role and molecular mechanism of D-aspartic acid in the nervous and neuroendocrine systems. Brain Research Bulletin, 80(5), 295-304. Melis, M. R., et al. (2016). The role of D-aspartic acid in the control of hormone secretion and ovulation. Reproductive Biology and Endocrinology, 14(1), 1-12.
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