D-Panthenol (provitamin B5) moisturizes, heals wounds, and repairs skin barriers in topical cosmetics with rare irritation.
D-Panthenol, also known as provitamin B5, is a synthetic humectant and emollient with moisturizing, wound-healing, and skin barrier-repairing properties. It is commonly used in topical cosmetic and pharmaceutical formulations for skin and hair care due to its ability to attract and retain moisture, promote tissue regeneration, and reduce inflammation. While generally safe, rare instances of skin irritation or gastrointestinal upset have been reported.
Key Information
Outside Body Harmful Score
Common Dosage
Dosage varies widely depending on application. In topical applications (creams, lotions), concentrations typically range from 0.5% to 5%. Oral supplementation is less common, but dosages of 50-500mg daily have been used in some studies.
Source Type
synthetic
Production Process
D-Panthenol is synthesized through chemical processes, typically involving the reaction of 3-aminopropanol with pantolactone. Different synthetic routes exist, but they generally involve controlled chemical reactions to achieve the desired stereoisomer.
Use Type
Outside BodyPotential Benefits
Skin hydration is essential for maintaining skin elasticity, barrier function, and overall appearance. It reduces fine lines, protects against environmental stressors, and improves skin smoothness and suppleness.
This benefit focuses on restoring and maintaining the skin's natural barrier to protect against environmental factors and maintain hydration and elasticity. It involves using ingredients like ceramides and humectants to reduce dryness and irritation.
Accelerates and supports the body's natural wound repair processes. This includes reducing inflammation, promoting collagen synthesis, increasing cell proliferation, and facilitating angiogenesis, leading to faster wound closure, reduced scarring, and decreased infection risk.
Supports hair strength and reduces shedding, especially in individuals with biotin deficiency. Mechanisms may include enhanced keratin production.
This benefit reduces inflammation by modulating inflammatory pathways and inhibiting pro-inflammatory cytokines, resulting in reduced pain, swelling, and improved function. It is beneficial for conditions like arthritis, inflammatory bowel disease, cardiovascular disease, and skin conditions.
Possible Side Effects
May cause mild digestive discomfort.
Skin irritation involves symptoms like redness, itching, and rashes due to contact with irritants, allergens, or environmental factors. Severity varies based on the cause, individual sensitivity, and affected area; persistent cases may lead to secondary infections.
Scientific Evidence
Proksch E, de Jongh CM, Dähnhardt D, Ludemann J, Ring J. Topical use of dexpanthenol: a 70th anniversary article. J Dermatolog Treat. 2017 Dec;28(8):766-773. Camargo FB Jr, Gaspar LR, Maia Campos PM. Skin moisturizing effects of panthenol-based formulations. J Cosmet Sci. 2011 Jul-Aug;62(4):361-9.
User Reviews
Share your experience with this ingredient
Log in to write a reviewNo reviews yet. Be the first to share your experience!