Hesperidin is a bioflavonoid found in citrus fruits used to support cardiovascular health, reduce inflammation, and manage venous insufficiency.
Hesperidin is a citrus bioflavonoid known for its antioxidant and anti-inflammatory properties. It is primarily used to support cardiovascular health, reduce inflammation, and manage symptoms of venous insufficiency. It may also have antioxidant effects. While generally safe, mild side effects such as stomach upset or headache can occur in some individuals. Dosages typically range from 50-500mg daily, but consultation with a healthcare professional is recommended.
Key Information
Inside Body Harmful Score
Common Dosage
50-500mg daily
Source Type
natural
Production Process
Hesperidin is primarily extracted from citrus fruits, particularly from the peels and pulp. Extraction methods vary but commonly involve solvent extraction followed by purification and crystallization.
Use Type
Inside BodyPotential Benefits
Antioxidant support protects cells from damage by neutralizing free radicals, supporting immune function, and reducing inflammation. It contributes to overall health and may reduce the risk of chronic diseases.
Supports cardiovascular health.
Reduces inflammation by inhibiting inflammatory pathways and the production of inflammatory molecules, thereby alleviating symptoms and protecting against tissue damage. This benefit helps modulate inflammatory responses and promote resolution.
Aged garlic extract acts as an antioxidant by neutralizing free radicals, protecting cells from damage and potentially reducing the risk of chronic diseases. The allicin-derived metabolites are the active components.
Hesperidin and diosmin combination helps alleviate venous insufficiency symptoms like leg pain, swelling, and heaviness by strengthening blood vessel walls and improving blood flow.
Diosmin and hesperidin are used to treat acute hemorrhoidal attacks. They reduce pain, bleeding, and swelling by improving venous tone and reducing inflammation.
Diosmin, especially when combined with hesperidin, can help heal venous leg ulcers by improving blood flow and reducing inflammation in the affected area. This aids in tissue repair and reduces swelling and discomfort.
Possible Side Effects
Headache is pain in the head ranging from mild to severe, potentially with nausea, light/sound sensitivity, or dizziness. It can be caused by tension, dehydration, stress, or medication side effects, and persistent headaches require medical evaluation.
Stomach upset involves abdominal pain, cramping, bloating, and potential diarrhea, nausea, or vomiting. Severity varies depending on individual sensitivities and underlying conditions.
Scientific Evidence
Numerous studies have investigated hesperidin's effects on cardiovascular health, inflammation, and venous insufficiency. Key scientific sources include research articles published in journals such as the American Journal of Clinical Nutrition, the Journal of Nutritional Biochemistry, and the International Journal of Angiology. Research frequently combines hesperidin with diosmin, making it difficult to isolate effects.
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