Idebenone is a synthetic analog of coenzyme Q10, known for its antioxidant and mitochondrial-enhancing properties. It is primarily used to improve cognitive function and treat conditions associated wi...
Idebenone is a synthetic analog of coenzyme Q10, known for its antioxidant and mitochondrial-enhancing properties. It is primarily used to improve cognitive function and treat conditions associated with mitochondrial dysfunction, including Leber's Hereditary Optic Neuropathy (LHON). While generally well-tolerated, some individuals may experience mild side effects such as gastrointestinal upset or agitation.
Key Information
Outside Body Harmful Score
Common Dosage
45-90mg daily, divided into multiple doses
Source Type
synthetic
Production Process
Idebenone is synthesized through a multi-step chemical process involving the reaction of a quinone derivative with an isoprenoid side chain. The specific synthetic routes vary depending on the manufacturer but generally involve organic chemistry techniques.
Use Type
Outside BodyPotential Benefits
Protects cells from damage by neutralizing free radicals.
Cognitive enhancement improves mental performance by boosting memory, attention, and processing speed. It works by promoting neuronal health and protecting against cognitive decline.
Idebenone improves mitochondrial function by enhancing electron transport chain efficiency, resulting in increased cellular energy production. This is particularly helpful for individuals with mitochondrial dysfunction.
Idebenone is used to treat Leber's Hereditary Optic Neuropathy (LHON) by improving or stabilizing visual acuity. It acts as an electron carrier in mitochondria to improve cellular energy and reduce oxidative stress.
Possible Side Effects
Headache is pain in the head ranging from mild to severe, potentially with nausea, light/sound sensitivity, or dizziness. It can be caused by tension, dehydration, stress, or medication side effects, and persistent headaches require medical evaluation.
Gastrointestinal disturbances include nausea, vomiting, and diarrhea. These symptoms indicate irritation or inflammation in the digestive tract.
Agitation and irritability involve feelings of unease, frustration, and restlessness, potentially accompanied by insomnia. This side effect can impact daily functioning.
Scientific Evidence
Laliberte F, Veenstra DL, Goodkin DE, McCarty D, Patrick AR, Stephens JM. Cost-effectiveness of idebenone in patients with Leber's hereditary optic neuropathy. J Med Econ. 2015;18(3):208-19. Klopstock T, Yu-Wai-Man P, Dimitriadis K, Rouleau J, Heck S, Bailie M, Micek A, Arevalo N, Dreyhaupt J, Meier T; RHODOS Study Group. A randomized placebo-controlled trial of idebenone in Leber's hereditary optic neuropathy. Brain. 2011 Nov;134(Pt 11):3415. Rustin P, Munnich A, Rötig A. Antioxydants en pathologie mitochondriale. Med Sci (Paris). 2000 Mar;16(3):347-53.
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