Inositol plays a critical role in cell signaling and neurotransmitter activity, managing PCOS, anxiety, and insulin resistance.
Inositol, a sugar-like molecule often mistakenly called vitamin B8, is crucial for various cellular functions, including cell signaling, insulin sensitivity, and neurotransmitter regulation. Primarily found in two forms, myo-inositol and D-chiro-inositol, it's naturally synthesized within the body and available through dietary sources. Supplementation is frequently employed to address conditions like PCOS, anxiety, depression, insulin resistance, and OCD. While generally considered safe, high dosages may induce gastrointestinal discomfort. Research indicates its potential in improving insulin sensitivity, hormonal balance in PCOS, and reducing symptoms of certain mental health conditions.
Key Information
Inside Body Harmful Score
Common Dosage
200mg - 4g daily, depending on the condition being addressed. Higher doses are typically used for PCOS and mental health conditions.
Source Type
natural
Production Process
Inositol is naturally produced in the body from glucose. It can also be extracted from plant sources like grains, nuts, and fruits, or synthesized chemically.
Use Type
Inside BodyPotential Benefits
Reduces anxiety.
Inositol improves insulin sensitivity, regulates menstrual cycles, and increases fertility in women with PCOS by enhancing insulin signaling and ovarian function.
Inositol supplementation, particularly at high doses (up to 18 grams daily), may alleviate anxiety and panic disorder symptoms by affecting serotonin signaling. The exact mechanism requires further research.
Manages depression.
Inositol improves insulin sensitivity by enhancing glucose uptake and utilization in cells, particularly benefiting individuals with insulin resistance or type 2 diabetes. This effect is achieved through improved insulin receptor signaling and GLUT4 translocation.
Inositol may help alleviate OCD symptoms by modulating serotonin pathways. High doses are needed to potentially reduce obsessive thoughts and compulsive behaviors.
Possible Side Effects
May cause mild digestive discomfort.
Dizziness is a sensation of lightheadedness, unsteadiness, or vertigo that can arise from multiple causes. It can lead to falls or loss of consciousness in some cases.
Headache is pain in the head ranging from mild to severe, potentially with nausea, light/sound sensitivity, or dizziness. It can be caused by tension, dehydration, stress, or medication side effects, and persistent headaches require medical evaluation.
Fatigue is a common symptom of perceived lack of physical and/or mental energy interfering with daily activities. It can be caused by various factors and manifests differently in intensity and duration.
Scientific Evidence
Numerous studies in journals like the American Journal of Clinical Nutrition, Fertility and Sterility, and the Journal of Clinical Psychopharmacology have investigated the effects of inositol on PCOS, mental health disorders, and insulin resistance. Further research is continuously being conducted to explore the full range of its potential benefits and optimal usage.
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