Licorice root extract (Glabridin) is a natural compound derived from the licorice plant, *Glycyrrhiza glabra*. It's commonly used topically for its skin-brightening, anti-inflammatory, and antioxidant...
Licorice root extract (Glabridin) is a natural compound derived from the licorice plant, *Glycyrrhiza glabra*. It's commonly used topically for its skin-brightening, anti-inflammatory, and antioxidant properties. Glabridin inhibits tyrosinase, reducing melanin production, thus addressing hyperpigmentation. It also helps soothe irritated skin and protect against free radical damage. While generally safe for topical use, some individuals may experience mild skin irritation or allergic reactions.
Key Information
Outside Body Harmful Score
Common Dosage
25-100mg daily
Source Type
natural
Production Process
Licorice root extract (specifically glabridin) is derived from the root of the *Glycyrrhiza glabra* plant. The roots are typically harvested, dried, and then extracted using solvents such as ethanol or water. The extract is then processed to isolate and concentrate glabridin.
Use Type
Outside BodyPotential Benefits
This benefit reduces inflammation by modulating inflammatory pathways and inhibiting pro-inflammatory cytokines, resulting in reduced pain, swelling, and improved function. It is beneficial for conditions like arthritis, inflammatory bowel disease, cardiovascular disease, and skin conditions.
Antioxidants neutralize harmful free radicals, preventing cellular damage and reducing oxidative stress, which can contribute to overall health and disease prevention. They work by donating electrons to stabilize free radicals and supporting antioxidant enzyme systems.
Skin brightening aims to lighten skin tone and reduce hyperpigmentation through melanin inhibition, exfoliation, and protection against UV damage. This results in a more even and radiant complexion.
Ectoin offers protection against UV-induced skin damage by reducing sunburn cell formation and supporting DNA repair. It's not a replacement for sunscreen but provides additional protection.
Possible Side Effects
Skin irritation involves symptoms like redness, itching, and rashes due to contact with irritants, allergens, or environmental factors. Severity varies based on the cause, individual sensitivity, and affected area; persistent cases may lead to secondary infections.
Allergic reactions are hypersensitivity responses to allergens, ranging from mild skin irritation to life-threatening anaphylaxis. Symptoms vary widely and are caused by an immune response.
Scientific Evidence
Several studies have demonstrated the efficacy of glabridin in skin brightening and reducing hyperpigmentation (e.g., Fujimura et al., 2000; Saeedi et al., 2003). Research also supports its anti-inflammatory and antioxidant properties (e.g., Yokota et al., 1998). Further studies are ongoing to explore its potential benefits and optimal usage.
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