Menaquinone-7 (MK-7) is a form of vitamin K2 that plays a crucial role in bone and cardiovascular health. Produced primarily through bacterial fermentation, it activates proteins involved in calcium m...
Menaquinone-7 (MK-7) is a form of vitamin K2 that plays a crucial role in bone and cardiovascular health. Produced primarily through bacterial fermentation, it activates proteins involved in calcium metabolism, directing calcium to bones and preventing its accumulation in arteries. While generally safe, potential interactions with anticoagulant medications should be considered.
Key Information
Inside Body Harmful Score
Common Dosage
45-180 mcg daily
Source Type
natural
Production Process
Menaquinone-7 (MK-7) is primarily produced through bacterial fermentation, often using Bacillus subtilis natto. The bacteria convert precursors into MK-7 during the fermentation process. It can also be extracted from fermented foods like natto.
Use Type
Inside BodyPotential Benefits
Enhances bone density, strength, and integrity by supporting bone formation, calcium absorption, and reducing age-related bone loss. Improves overall skeletal health and function, ultimately reducing the risk of fractures.
Supports cardiovascular health.
Possible Side Effects
MK-7 can interfere with the effectiveness of anticoagulant medications like warfarin, potentially increasing the risk of blood clot formation. Individuals taking these medications should consult their healthcare provider before taking MK-7 supplements to ensure appropriate monitoring and dosage adjustments.
High doses of MK-7 may cause mild gastrointestinal discomfort such as nausea or upset stomach. Symptoms are typically mild and transient.
Scientific Evidence
Rawlik, S., et al. "Vitamin K2-dependent proteins: from coagulation to calcification." Vitamins & Hormones 78 (2008): 355-386. Sato, T., et al. "Menaquinone-7 improves bone quality and calcium deposition in lumbar vertebrae in postmenopausal women with osteopenia." Osteoporosis International 26.4 (2015): 1243-1251. Knapen, M. H., et al. "Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women." Thrombosis and Haemostasis 113.5 (2015): 1135-1144.
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