Nicotinamide Mononucleotide (NMN) is a naturally occurring nucleotide and a precursor to nicotinamide adenine dinucleotide (NAD+), a vital coenzyme in all living cells. NMN supplementation is purporte...
Nicotinamide Mononucleotide (NMN) is a naturally occurring nucleotide and a precursor to nicotinamide adenine dinucleotide (NAD+), a vital coenzyme in all living cells. NMN supplementation is purported to increase NAD+ levels, potentially leading to benefits such as improved energy metabolism, enhanced insulin sensitivity, and anti-aging effects. While research is ongoing, preliminary studies, particularly in animal models, show promising results. Human trials are underway to further validate these potential benefits and determine the long-term safety of NMN supplementation. Side effects appear to be mild and infrequent at commonly used dosages.
Key Information
Inside Body Harmful Score
Common Dosage
250-500mg daily
Source Type
natural
Production Process
NMN is naturally produced in the body. Industrially, it can be produced through enzymatic synthesis using nicotinamide riboside (NR) as a precursor, or through chemical synthesis involving multiple steps. Enzymatic synthesis is often preferred due to higher purity and efficiency.
Use Type
Inside BodyPotential Benefits
Cardiovascular health ensures efficient blood circulation by maintaining healthy heart and blood vessels. Benefits include reduced risk of heart disease and stroke through improved blood flow and heart function.
NAD+ boosts sirtuin activity, which are proteins involved in regulating aging. Supplementing with NR to increase NAD+ might promote healthy aging and longevity, though more research is needed.
Supplementation with NMN is thought to increase NAD+ levels, a crucial coenzyme for cellular energy metabolism and DNA repair. Boosting NAD+ supports cellular health and may offer anti-aging benefits.
NMN boosts NAD+ levels, potentially enhancing cellular energy production and metabolism. This may lead to reduced fatigue and improved physical performance.
NMN shows potential for improving insulin sensitivity by enhancing glucose metabolism, based on preclinical studies. Human studies are needed to confirm these effects and determine safe and effective dosages.
NMN supplementation increases NAD+ levels, a vital coenzyme for energy metabolism, DNA repair, and gene expression. Boosting NAD+ may improve cellular function and counteract age-related decline.
NMN boosts NAD+ levels, enhancing mitochondrial function and energy production. This may improve physical endurance and reduce fatigue.
NMN supplementation may increase NAD+ levels and potentially slow down the aging process by promoting cellular repair and regeneration. Human studies are limited, but animal studies show promise.
Possible Side Effects
Headache is pain in the head ranging from mild to severe, potentially with nausea, light/sound sensitivity, or dizziness. It can be caused by tension, dehydration, stress, or medication side effects, and persistent headaches require medical evaluation.
Gastrointestinal discomfort includes nausea, bloating, and diarrhea, typically mild and transient. Symptoms are often dose-dependent and vary in severity.
Flushing is a temporary redness of the skin, similar to a niacin flush, experienced by some individuals after taking NR. It's generally harmless and resolves on its own.
Scientific Evidence
Key studies include research on NMN's effects on NAD+ levels, glucose metabolism, and aging in animal models. Human clinical trials are increasingly available, although long-term data is still limited. Search for studies on PubMed and other scientific databases using keywords like 'nicotinamide mononucleotide,' 'NMN,' and 'NAD+.'
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