Tocotrienols are a group of fat-soluble compounds belonging to the vitamin E family, distinct from tocopherols. They are extracted from various plant sources and are available as dietary supplements....
Tocotrienols are a group of fat-soluble compounds belonging to the vitamin E family, distinct from tocopherols. They are extracted from various plant sources and are available as dietary supplements. Research suggests potential benefits in neuroprotection, cardiovascular health, and cancer prevention. Common dosages range from 50-200mg daily. While generally considered safe, gastrointestinal upset and potential interactions with medications are possible. Consultation with a healthcare professional is advised before use, especially for those with pre-existing conditions or taking medications.
Key Information
Inside Body Harmful Score
Common Dosage
50-200mg daily
Source Type
natural
Production Process
Extracted from plant sources such as rice bran, palm oil, annatto, and barley. The extraction process typically involves solvent extraction followed by purification and concentration.
Use Type
Inside BodyPotential Benefits
Enhances bone density, strength, and integrity by supporting bone formation, calcium absorption, and reducing age-related bone loss. Improves overall skeletal health and function, ultimately reducing the risk of fractures.
Cardiovascular health ensures efficient blood circulation by maintaining healthy heart and blood vessels. Benefits include reduced risk of heart disease and stroke through improved blood flow and heart function.
Neuroprotection aims to protect the brain and nervous system from damage and degeneration by preventing neuronal cell death, reducing inflammation, and enhancing synaptic plasticity. Strategies include lifestyle modifications, nutritional supplementation, and pharmacological interventions to mitigate effects of aging, neurodegenerative diseases, stroke, and traumatic brain injury.
Tocotrienols demonstrate anti-cancer activity by inhibiting cancer cell growth, inducing apoptosis, and suppressing angiogenesis. These effects have been observed in breast, prostate, and colon cancer cells.
Possible Side Effects
Gastrointestinal upset involves a variety of digestive symptoms like nausea, diarrhea, and abdominal pain. It can range from mild discomfort to severe pain and may indicate an underlying condition if persistent.
Bleeding risk indicates an increased chance of hemorrhage, either spontaneously or after minor injury, due to impaired platelet function, coagulation issues, or damaged blood vessels. Severity can range from minor bruising to life-threatening internal bleeding.
Increased bleeding risk occurs due to interference with blood clotting, potentially leading to prolonged bleeding, easy bruising, or internal bleeding. This risk is amplified by anticoagulant/antiplatelet medications or pre-existing bleeding disorders.
Drug interactions can alter a drug's effectiveness, leading to either increased risk of blood clots or bleeding, particularly with anticoagulants. Monitoring is essential to manage these interactions.
Scientific Evidence
Studies published in journals like the 'American Journal of Clinical Nutrition,' 'Journal of Nutritional Biochemistry,' and 'Free Radical Biology and Medicine' have explored the effects of tocotrienols on various health outcomes.
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