Generally Safe

Vitamin K1 is generally safe with rare adverse effects. Allergic reactions are possible, especially with intravenous administration, and high doses may interact with anticoagulants.

Vitamin K1 (phylloquinone) is generally well-tolerated at recommended dosages. Adverse effects are rare, but may include allergic reactions, particularly with intravenous administration. Symptoms of allergic reactions can range from mild skin rashes and itching to more severe anaphylactic reactions, though the latter are exceedingly rare. High doses may interfere with anticoagulant medications like warfarin, necessitating dosage adjustments.