Iron Overload

High doses of L-ascorbic acid (Vitamin C) can worsen iron overload in individuals with hemochromatosis by increasing iron absorption, leading to potential organ damage.

In individuals with hemochromatosis (iron overload), high doses of L-ascorbic acid (Vitamin C) can significantly exacerbate iron accumulation in the body. This is because L-ascorbic acid enhances the absorption of non-heme iron from the diet. The excess iron can deposit in organs like the liver, heart, and pancreas, leading to organ damage, cirrhosis, heart failure, diabetes, and other serious health problems. Symptoms can include fatigue, joint pain, abdominal pain, skin discoloration, and irregular heartbeat. The extent of the effect depends on the dosage of L-ascorbic acid and the pre-existing level of iron overload in the individual.