Skin Rashes

High-dose biotin supplementation can paradoxically cause skin rashes, including maculopapular, erythematous, or urticarial eruptions. The cause is not fully understood but may involve altered immune responses or vitamin metabolism interference.

Skin rashes associated with high-dose biotin supplementation are a paradoxical and relatively uncommon adverse effect. These rashes can manifest as various types of skin eruptions, including maculopapular rashes (small, raised bumps), erythematous rashes (reddened skin), or urticaria (hives). The underlying mechanism is not fully understood but is hypothesized to be related to altered immune responses or interference with the absorption or metabolism of other vitamins. The rash may be accompanied by itching (pruritus) or discomfort. These rashes can occur even in individuals without prior history of skin conditions or allergies. While generally considered mild, persistent or severe rashes may require medical evaluation to rule out other potential causes and implement appropriate management.