Astragalus Polysaccharides (APS) are bioactive compounds derived from Astragalus membranaceus root, valued for their potential to modulate the immune system, reduce inflammation, provide antioxidant p...
Astragalus Polysaccharides (APS) are bioactive compounds derived from Astragalus membranaceus root, valued for their potential to modulate the immune system, reduce inflammation, provide antioxidant protection, and support cardiovascular health. These effects are attributed to their ability to stimulate immune cells, inhibit pro-inflammatory cytokines, and scavenge free radicals. While generally considered safe, mild gastrointestinal discomfort and rare allergic reactions are possible. Caution is warranted regarding potential interactions with immunosuppressants and blood thinners. Further research is needed to solidify the clinical efficacy and fully understand the mechanisms of action of APS.
Key Information
Inside Body Harmful Score
Common Dosage
Varies depending on the specific extract and intended use, but generally ranges from 500mg to 3g daily.
Source Type
natural
Production Process
Extracted from the root of Astragalus membranaceus, typically using hot water or ethanol extraction methods, followed by purification and concentration steps to isolate the polysaccharides.
Use Type
Inside BodyPotential Benefits
Immune modulation balances the immune system by either boosting it during deficiencies or suppressing it during overactivity, aiming to restore immune homeostasis. This can be achieved through influencing cytokine production, regulating immune cell activity and promoting self-tolerance.
This benefit reduces inflammation by modulating inflammatory pathways and inhibiting pro-inflammatory cytokines, resulting in reduced pain, swelling, and improved function. It is beneficial for conditions like arthritis, inflammatory bowel disease, cardiovascular disease, and skin conditions.
Antioxidants neutralize harmful free radicals, preventing cellular damage and reducing oxidative stress, which can contribute to overall health and disease prevention. They work by donating electrons to stabilize free radicals and supporting antioxidant enzyme systems.
Antioxidants protect cells from damage caused by free radicals, reducing inflammation, and promoting overall health. They neutralize these unstable molecules by donating electrons and preventing them from damaging cellular structures.
Reduces inflammation by inhibiting inflammatory pathways and the production of inflammatory molecules, thereby alleviating symptoms and protecting against tissue damage. This benefit helps modulate inflammatory responses and promote resolution.
Astragalus polysaccharides may protect the cardiovascular system by improving endothelial function, reducing blood pressure and cholesterol, and providing antioxidant defense against oxidative stress. This can contribute to overall heart health.
APS may combat viral infections by disrupting viral replication and enhancing the immune response. This combined action can aid in reducing the impact and length of viral illnesses.
Possible Side Effects
Allergic reactions are hypersensitivity responses to allergens, ranging from mild skin irritation to life-threatening anaphylaxis. Symptoms vary widely and are caused by an immune response.
Drug interactions can alter a drug's effectiveness, leading to either increased risk of blood clots or bleeding, particularly with anticoagulants. Monitoring is essential to manage these interactions.
Gastrointestinal discomfort includes nausea, bloating, and diarrhea, typically mild and transient. Symptoms are often dose-dependent and vary in severity.
GSE can trigger allergic reactions in individuals sensitive to grapefruit or other citrus fruits. Symptoms range from mild skin irritation to potentially life-threatening anaphylaxis.
GSE can interact with medications metabolized by cytochrome P450 enzymes, increasing drug levels and the risk of side effects. Monitoring is crucial when GSE is co-administered with such drugs.
Mild gastrointestinal discomfort includes bloating, gas, and diarrhea. Symptoms are generally mild and transient.
Scientific Evidence
Studies available on PubMed and Google Scholar regarding Astragalus Polysaccharides and their effects on immunity, inflammation, and cardiovascular health. Further key studies are needed to confirm the efficacy.
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