About NMN
Nicotinamide Mononucleotide (NMN) is a naturally occurring nucleotide and a precursor to nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme for cellular energy production and various other biological processes. Supplementation with NMN aims to increase NAD+ levels, which decline with age. Research suggests potential benefits including improved insulin sensitivity, enhanced energy metabolism, and potential anti-aging effects. While generally considered safe, some users may experience mild gastrointestinal discomfort or flushing. More research, especially in human clinical trials, is needed to fully understand the long-term effects and optimal dosage of NMN.
Key Information
Compare All Forms
Compare different forms of NMN by bioavailability, conversion rates, and active ingredient content:
| Form | Tier | Steps |
NMN (mg) |
Bioavailability | Action |
|---|---|---|---|---|---|
|
NMN (Nicotinamide Mononucleotide)
NMN aims to increase NAD+ for anti-aging and metabolic benef... |
Tier 2 | 1 | — | Moderate bioavailability form. Reliable form that works well but requires 1-2 step conversions by the body. Good balance of cost and effectiveness. | View → |
Scientific Evidence
Rajman, L., Chwalek, K., & Sinclair, D. A. (2018). Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell Metabolism, 27(3), 529–547.; Yoshino, J., Mills, K. F., Yoon, M. J., & Imai, S. I. (2011). Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice. Cell Metabolism, 14(4), 528–536.; Keisuke Okabe, Yusuke Yaku, Yoichi Tobe, Mitsuyoshi Tanaka. Implications of impaired NAD metabolism in metabolic diseases. Journal of Nutritional Science and Vitaminology. 2019, 65, Supplement, S14-S16