Glucosamine is an amino sugar used as a dietary supplement to support joint health and alleviate pain, often in combination with chondroitin.
Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. It is part of the structure of chitin and chitosan, which are polysaccharides that compose the exoskeleton of crustaceans and other arthropods, as well as the cell walls of fungi and many higher organisms. Glucosamine is commonly used as a dietary supplement, often in combination with chondroitin sulfate, to alleviate joint pain and stiffness, particularly in osteoarthritis.
Key Information
Inside Body Harmful Score
Common Dosage
1500 mg daily, typically divided into three doses
Source Type
Natural (derived from shellfish) or Synthetic
Production Process
Glucosamine is typically produced through the hydrolysis of chitin, which is extracted from crustacean shells. It can also be synthesized in the lab.
Use Type
Inside BodyPotential Benefits
Joint Health enhances joint function by supporting cartilage and reducing inflammation. It alleviates pain and stiffness associated with conditions like osteoarthritis.
Reduces joint pain associated with osteoarthritis.
Joint mobility enhances the range of motion, reduces stiffness and pain, and improves the ability to perform physical activities by improving flexibility, reducing inflammation, and optimizing joint lubrication. This results in easier and more extensive joint movement.
Connective tissue health ensures the strength, elasticity, and repair capabilities of cartilage, tendons, ligaments, bones, skin, and blood vessels. It supports structural integrity, joint function, and reduces injury risk by promoting collagen synthesis and reducing inflammation.
Enhances the body's natural healing after injury by reducing inflammation, promoting tissue regeneration, and restoring function. This multifaceted approach involves optimizing nutrient intake and promoting blood flow to the injury site.
Possible Side Effects
May cause mild digestive discomfort.
Risk of allergic reaction in individuals with shellfish allergies.
Glucosamine may slightly increase blood sugar levels, especially in individuals with diabetes. Monitoring blood glucose is recommended.
Scientific Evidence
Numerous studies have investigated glucosamine's efficacy in treating osteoarthritis, with mixed results. Some studies show significant pain reduction and improved joint function, while others report minimal benefits. Research suggests that glucosamine sulfate may be more effective than glucosamine hydrochloride. The effect on joint structure is still under investigation. (See: National Institutes of Health, Mayo Clinic)
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