L-Citrulline boosts nitric oxide production, improving blood flow, exercise performance, and potentially erectile dysfunction.
L-Citrulline is a non-essential amino acid that boosts nitric oxide production via the L-arginine pathway. This leads to vasodilation and improved blood flow, potentially enhancing exercise performance, reducing muscle soreness, and aiding in erectile dysfunction. While generally well-tolerated, gastrointestinal discomfort and hypotension are possible side effects. Caution is advised for individuals with low blood pressure or those taking blood pressure medications. Supplementation typically ranges from 3-6g daily, taken before exercise.
Key Information
Inside Body Harmful Score
Common Dosage
3-6g daily, often taken 30-60 minutes before exercise
Source Type
natural
Production Process
L-Citrulline is naturally occurring, often extracted from watermelons. It can also be produced synthetically through chemical synthesis.
Use Type
Inside BodyPotential Benefits
Improves blood flow for enhanced nutrient and oxygen delivery, resulting in performance, recovery, cardiovascular, cognitive, and skin health benefits. This is achieved through improved circulation and vasodilation.
Improves physical capabilities during exercise by enhancing strength, endurance, and recovery. This leads to better athletic performance and body composition.
Supports healthy blood pressure levels to reduce the risk of cardiovascular complications by promoting vasodilation, arterial elasticity, and healthy blood volume.
Creatine supplementation boosts exercise performance by increasing phosphocreatine, improving ATP regeneration for enhanced power, reduced fatigue, and better endurance during high-intensity activities. This benefit is especially helpful during short bursts of repeated high-intensity exercise.
L-Citrulline increases nitric oxide production, leading to vasodilation and improved blood flow. This enhances oxygen delivery throughout the body.
L-Citrulline enhances exercise performance by increasing blood flow to muscles, reducing fatigue, and improving endurance. This is achieved through increased nitric oxide production and vasodilation.
L-Citrulline may reduce muscle soreness after intense exercise by promoting waste removal and nutrient delivery to muscles, leading to faster recovery and reduced discomfort.
L-Citrulline enhances nitric oxide production, improving blood flow and potentially alleviating mild to moderate erectile dysfunction. It converts to L-Arginine in the body which increases nitric oxide (NO) which is responsible for vasodilation.
GABA may lower blood pressure in hypertensive individuals by acting as an inhibitory neurotransmitter and promoting vasodilation. It reduces neuronal excitability, influencing the autonomic nervous system to regulate vascular tone.
Possible Side Effects
May cause mild digestive discomfort.
Gastrointestinal discomfort includes nausea, bloating, and diarrhea, typically mild and transient. Symptoms are often dose-dependent and vary in severity.
L-Citrulline lowers blood pressure by increasing nitric oxide. This can cause dizziness or fainting, especially in people with low blood pressure or those taking blood pressure medication.
Hypotension is low blood pressure that can lead to dizziness, fainting, and in severe cases, shock. Taurine supplementation may contribute to hypotension in susceptible individuals.
Scientific Evidence
PMID: 11923286, PMID: 21660589, PMID: 20386125, PMID: 21425021
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