L-Glutamine supports gut health, immune function, and muscle recovery as a conditionally essential amino acid.
L-Glutamine is a conditionally essential amino acid critical for maintaining gut health, supporting immune function, and promoting muscle recovery. It serves as a key energy source for intestinal and immune cells, playing a crucial role in maintaining intestinal barrier integrity and enhancing immune cell activity. While generally safe, supplementation at high doses may lead to gastrointestinal discomfort, and potential interactions with medications should be considered. Consultation with a healthcare provider is recommended before starting L-Glutamine supplementation, especially for individuals with pre-existing medical conditions or those taking medications.
Key Information
Inside Body Harmful Score
Common Dosage
5-20g daily, divided into multiple doses
Source Type
natural
Production Process
L-Glutamine is typically produced via microbial fermentation using genetically modified microorganisms, or chemically synthesized.
Use Type
Inside BodyPotential Benefits
Gut health supports the digestive system by optimizing digestion, nutrient absorption, immune function, and waste elimination through a balanced gut microbiome. Maintaining gut health can reduce inflammation, improve digestion, and enhance overall well-being.
Recovery restores the body to equilibrium after stress, reducing injury risk and improving performance. It involves tissue repair, energy replenishment, and hormonal balance.
Accelerates and supports the body's natural wound repair processes. This includes reducing inflammation, promoting collagen synthesis, increasing cell proliferation, and facilitating angiogenesis, leading to faster wound closure, reduced scarring, and decreased infection risk.
Supports the body's defense against pathogens, enhances immune cell activity, and reduces inflammation. Improved immune function leads to fewer infections and faster recovery.
Glutamine may aid muscle recovery by reducing soreness, promoting tissue repair after intense exercise, replenishing glycogen stores, and minimizing muscle protein breakdown. It potentially achieves this by reducing inflammation and oxidative stress.
Possible Side Effects
Hypothetically, this substance can cause mild skin irritation with redness, itching, and burning at the application site, resolving on its own.
Allergic reactions are hypersensitivity responses to allergens, ranging from mild skin irritation to life-threatening anaphylaxis. Symptoms vary widely and are caused by an immune response.
Gastrointestinal issues include nausea, diarrhea, abdominal discomfort, and vomiting, potentially stemming from altered gut motility, microbiota changes, or irritation. While often mild, persistent symptoms necessitate evaluation, and contributing factors like pre-existing conditions should be considered.
L-Glutamine may interact with medications, particularly anti-seizure drugs, potentially altering their effectiveness or increasing the risk of side effects. Consultation with a healthcare professional is crucial before use if taking other medications.
Gastrointestinal discomfort includes nausea, bloating, and diarrhea, typically mild and transient. Symptoms are often dose-dependent and vary in severity.
Scientific Evidence
Key scientific sources and studies include research published in journals such as the American Journal of Clinical Nutrition, the Journal of Parenteral and Enteral Nutrition, and the International Journal of Sports Nutrition and Exercise Metabolism. Search terms can include: 'L-Glutamine intestinal permeability', 'L-Glutamine immune function', 'L-Glutamine muscle recovery', 'L-Glutamine wound healing'.
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