Polypeptides are short chains of amino acids linked by peptide bonds. They are smaller than proteins, typically consisting of 2 to 50 amino acids. Polypeptides play diverse roles in the body, includin...
Polypeptides are short chains of amino acids linked by peptide bonds. They are smaller than proteins, typically consisting of 2 to 50 amino acids. Polypeptides play diverse roles in the body, including serving as building blocks for proteins, acting as signaling molecules (hormones and neurotransmitters), and exhibiting antioxidant and antimicrobial properties. Supplementation with specific polypeptides, such as collagen peptides, is often used to support muscle growth and repair, improve skin health, and promote wound healing. However, the effects and safety of polypeptide supplementation can vary depending on the specific polypeptide, dosage, and individual factors. Consulting with a healthcare professional is recommended before using polypeptide supplements.
Key Information
Outside Body Harmful Score
Common Dosage
Dosage varies widely depending on the specific polypeptide and its intended use. Ranges can be from micrograms to grams daily, often administered in divided doses. It is crucial to consult with a healthcare professional to determine the appropriate dosage.
Source Type
hybrid
Production Process
Polypeptides can be produced through several methods: (1) Solid-phase peptide synthesis (SPPS), a chemical process where amino acids are sequentially added to a growing peptide chain attached to a solid support. (2) Recombinant DNA technology, where genes encoding specific polypeptides are introduced into microorganisms (e.g., bacteria or yeast) to produce the polypeptides. (3) Enzymatic synthesis, using enzymes to catalyze the formation of peptide bonds.
Use Type
Outside BodyPotential Benefits
This benefit aims to improve overall skin health and appearance through increased hydration, reduced inflammation, improved elasticity, and protection from environmental damage. Healthy skin exhibits a smooth texture, even tone, and strong barrier function.
Immune modulation balances the immune system by either boosting it during deficiencies or suppressing it during overactivity, aiming to restore immune homeostasis. This can be achieved through influencing cytokine production, regulating immune cell activity and promoting self-tolerance.
Accelerates and supports the body's natural wound repair processes. This includes reducing inflammation, promoting collagen synthesis, increasing cell proliferation, and facilitating angiogenesis, leading to faster wound closure, reduced scarring, and decreased infection risk.
Polypeptides support muscle growth, repair, and recovery by providing the building blocks for muscle protein synthesis. Collagen peptides may improve muscle mass and strength in older adults when combined with resistance training.
Possible Side Effects
Allergic reactions are hypersensitivity responses to allergens, ranging from mild skin irritation to life-threatening anaphylaxis. Symptoms vary widely and are caused by an immune response.
Gastrointestinal distress involves digestive discomfort like bloating, diarrhea, cramps, nausea, and vomiting. Severity varies based on individual factors and can be triggered by irritation or inflammation of the digestive tract.
High-dose collagen peptide supplementation can potentially lead to hypercalcemia, especially in individuals with kidney disease or those also taking calcium supplements. Symptoms can range from mild fatigue to severe cardiac arrhythmias.
Scientific Evidence
[PMID: 30185460] (Collagen supplementation for skin health), [PMID: 30681787] (Collagen peptides and muscle mass), [PMID: 28786550] (Wound healing peptides), [PMID: 31968576] (Immunomodulatory peptides)
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