Potential Tumorigenic Concerns (Theoretical)

Theoretical concerns exist that topical EGF could stimulate the growth of pre-existing cancerous cells. This risk is largely unproven for cosmetic use but warrants caution.

Theoretical concerns exist regarding the potential of Epidermal Growth Factor (EGF) to stimulate the growth of pre-existing pre-cancerous or cancerous cells when applied topically. This concern stems from EGF's role in cell proliferation and differentiation. While evidence is limited and primarily theoretical for topical cosmetic use in humans, the possibility of accelerated tumor growth in individuals with underlying, undiagnosed cancerous or pre-cancerous conditions cannot be definitively ruled out. More research is needed to fully understand the risks associated with topical EGF application.