About Vitamin K2
Vitamin K2 (Menaquinone-7 or MK-7) is a fat-soluble vitamin essential for bone and cardiovascular health, as well as blood clotting. It functions by activating proteins, such as osteocalcin and matrix Gla protein (MGP), that are involved in calcium regulation within the body. MK-7 directs calcium to bones, promoting bone density and strength, and inhibits calcium deposition in arteries, reducing arterial calcification. Sourced primarily through bacterial fermentation, MK-7 boasts superior bioavailability and a longer half-life compared to other forms of Vitamin K. While generally safe, potential interactions with anticoagulants warrant careful monitoring, and high doses may rarely cause mild gastrointestinal upset.
Key Information
Compare All Forms
Compare different forms of Vitamin K2 by bioavailability, conversion rates, and active ingredient content:
| Form | Tier | Steps |
Vitamin K2 Activity (mcg) |
Bioavailability | Action |
|---|---|---|---|---|---|
|
Vitamin K2 (MK-7)
Vitamin K2 (MK-7) directs calcium to bones, supporting bone... |
Tier 2 | 1 | — | Moderate bioavailability form. Reliable form that works well but requires 1-2 step conversions by the body. Good balance of cost and effectiveness. | View → |
|
Vitamin K2 (MK-4)
Vitamin K2 (MK-4) is important for blood clotting and bone h... |
Tier 3 | 3 | — | Basic/low bioavailability form. Cheap raw material with poor absorption or high GI distress. Often poorly utilized by the body, requires 3+ conversion steps. | View → |
Scientific Evidence
Numerous studies have demonstrated the efficacy of MK-7 in improving bone density and cardiovascular health markers. Key studies include research on the impact of MK-7 supplementation on bone mineral density in postmenopausal women and its effect on arterial stiffness. Research includes studies published in journals such as Osteoporosis International, Thrombosis and Haemostasis, and Nutrients.