Vitamin K2 (MK-7) directs calcium to bones, supporting bone and cardiovascular health, and has good bioavailability.
Vitamin K2 (Menaquinone-7 or MK-7) is a fat-soluble vitamin essential for bone and cardiovascular health, as well as blood clotting. It functions by activating proteins, such as osteocalcin and matrix Gla protein (MGP), that are involved in calcium regulation within the body. MK-7 directs calcium to bones, promoting bone density and strength, and inhibits calcium deposition in arteries, reducing arterial calcification. Sourced primarily through bacterial fermentation, MK-7 boasts superior bioavailability and a longer half-life compared to other forms of Vitamin K. While generally safe, potential interactions with anticoagulants warrant careful monitoring, and high doses may rarely cause mild gastrointestinal upset.
Key Information
Inside Body Harmful Score
Common Dosage
45-180 mcg daily
Source Type
natural
Production Process
Produced primarily through bacterial fermentation, often using Bacillus subtilis natto cultures.
Use Type
Inside BodyPotential Benefits
Enhances bone density, strength, and integrity by supporting bone formation, calcium absorption, and reducing age-related bone loss. Improves overall skeletal health and function, ultimately reducing the risk of fractures.
This benefit supports cardiovascular function by maintaining healthy blood pressure, cholesterol, and blood vessel elasticity, ultimately reducing the risk of heart disease. It also manages inflammation for overall heart health.
Supports cardiovascular health.
Blood clotting is a vital process that stops bleeding after injury by forming a stable clot. It involves a complex interaction of platelets and clotting factors.
Possible Side Effects
May cause mild digestive discomfort.
Clotting interactions can lead to either increased blood clot formation (thrombosis) or impaired clotting, potentially causing excessive bleeding. Severity ranges from superficial thrombophlebitis to life-threatening events like DVT, PE, stroke, or hemorrhage.
Drug interactions can alter a drug's effectiveness, leading to either increased risk of blood clots or bleeding, particularly with anticoagulants. Monitoring is essential to manage these interactions.
Scientific Evidence
Numerous studies have demonstrated the efficacy of MK-7 in improving bone density and cardiovascular health markers. Key studies include research on the impact of MK-7 supplementation on bone mineral density in postmenopausal women and its effect on arterial stiffness. Research includes studies published in journals such as Osteoporosis International, Thrombosis and Haemostasis, and Nutrients.
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