Polyglutamic acid (PGA) is a biopolymer excelling in skin hydration and showing potential in wound healing and nutrient absorption.
Polyglutamic acid (PGA) is a naturally derived biopolymer created through bacterial fermentation. It is primarily recognized for its potent hydrating properties in skincare, exceeding hyaluronic acid's water-retention capabilities. Preliminary research suggests potential benefits in wound healing and nutrient absorption, though more extensive studies are needed. Topical application is generally well-tolerated, but may induce minor skin irritation in sensitive individuals. Oral consumption is less common and could lead to mild digestive discomfort. PGA is an emerging ingredient with promising applications in both cosmetic and nutritional fields due to its biocompatibility and unique characteristics.
Key Information
Outside Body Harmful Score
Common Dosage
Dosage varies significantly depending on the application. No standardized oral dosage is established.
Source Type
natural
Production Process
Produced by bacterial fermentation
Use Type
Outside BodyPotential Benefits
Hydration ensures sufficient body water for optimal function, supporting processes like temperature regulation and nutrient transport. It prevents dehydration and associated symptoms like fatigue and cognitive impairment.
Skin hydration is essential for maintaining skin elasticity, barrier function, and overall appearance. It reduces fine lines, protects against environmental stressors, and improves skin smoothness and suppleness.
Anti-aging interventions protect cells from damage, promote cellular repair, and reduce the risk of age-related diseases. Strategies include dietary interventions, supplementation, lifestyle modifications, and topical treatments to improve overall health and well-being.
Accelerates and supports the body's natural wound repair processes. This includes reducing inflammation, promoting collagen synthesis, increasing cell proliferation, and facilitating angiogenesis, leading to faster wound closure, reduced scarring, and decreased infection risk.
Betaine HCL may improve nutrient absorption by increasing stomach acidity, particularly for vitamin B12, iron, and calcium. Adequate stomach acid is necessary for proper digestion and nutrient uptake.
PGA may improve mineral and nutrient absorption by increasing gut residence time. Further research is required to validate this effect.
Possible Side Effects
Skin irritation involves symptoms like redness, itching, and rashes due to contact with irritants, allergens, or environmental factors. Severity varies based on the cause, individual sensitivity, and affected area; persistent cases may lead to secondary infections.
Rarely, topical PGA application causes mild skin irritation like redness or itching, particularly in sensitive individuals. Symptoms are usually mild and self-resolving.
PGA oral consumption may cause mild digestive issues like bloating or gas in some individuals. These symptoms are usually temporary and mild.
Scientific Evidence
Limited clinical trials available. Search PubMed and Google Scholar for 'Polyglutamic Acid Benefits', 'Polyglutamic Acid Hydration', 'Polyglutamic Acid Wound Healing', and 'Polyglutamic Acid Side Effects'.
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